DUETs: Database of Uncertainties about the Effects of Treatments

There are many important uncertainties about the effects of treatments. To help ensure that treatments are likely to do more good than harm, these gaps in knowledge must be identified and those deemed sufficiently important must be addressed in research. Research on the effects of treatments too often fails to address questions that matter to patients, and to the clinicians to whom they turn for help. For this reason, the Database of Uncertainties about the Effects of Treatments (DUETs) gives priority to identifying and publishing unanswered questions about the effects of treatments which have been asked by patients and clinicians, while also noting therapeutic uncertainties identified through systematic reviews, clinical guidelines, and other formal mechanisms.